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Mdm2 is highly up-regulated under hypoxic conditions in Spalax in com-parison to other rats, pointing to its importance in adaptation to hypoxia [ 4 ].However, Mdm2 is up-regulated in another animal adapted to low oxygen, the red-eared slider turtle ( Trachemys scripta elegans), although other p53 target genes areaffected [ 57].

Eight patients inthe conventional therapy arm died over the course of the study,suggesting a survival benefit of epoprostenol (p = 0.003).

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