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NPs are promi-nent in the amygdala and hippocampal subicular complexand are present in association cortices in AD; similar toNFTs; however, they are less common in primary motor andvisual cortices. The bron-chiolar narrowing due to the high ?ows andpulmonary venous pressure produce interstitialand alveolar edema

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However, its usefulness is limited by deterioration ofrenal function over time, metabolic complications, and the increased risk for thedevelopment of secondary malignancies. The plasmamembrane at the site of the clear zone contains cell andextracellular m atrix adhesion m olecules that areresponsible for providing a tight seal between the plasmamembrane and mineralized matrix of the bone.

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